Conversation focused on a topic that is becoming increasingly important in reproductive medicine: how a more personalized understanding of LH activity may influence decision-making in both female and male infertility treatment. With global experts, new clinical frameworks, and emerging evidence now moving closer to daily practice, the discussion was centered not on theory alone, but on what may change in the way specialists think and act in real clinical settings.

Two lectures. Two frameworks. One question at the center: are we making gonadotropin decisions based on biology — or on habit? LH supplementation in women and endocrine phenotyping in men are not new topics. But the evidence base has shifted, and so have the tools available to clinicians. POSEIDON has changed how we think about poor ovarian response. APHRODITE is now changing how we classify male infertility. Both frameworks were presented here by the researchers who created them. This course captures that conversation — not as theory, but as a clinical argument for moving from empirical to phenotype-based decision-making.