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  5. Why do euploid embryos fail to implant.
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  7. Overweight, obesity and reproductive outcomes
Reproductive healthLecture

Overweight, obesity and reproductive outcomes

The impact of overweight and obesity on reproductive outcomes: ovarian response, embryo quality, endometrial receptivity and obstetric consequences. Why BMI alone is insufficient for clinical decisions — and how body composition assessment (bioelectrical impedance, indirect calorimetry, food diary) makes pre-cycle workup truly individualized.

Christophe Blockeel
Christophe Blockeel
Audio: MultiSubtitles: EN · UA · RU32 min
Christophe Blockeel

Christophe Blockeel

Professor, MD, PhD

Reproductive endocrinologist and gynecologist, and Medical Director of Brussels IVF — the Centre for Reproductive Medicine at University Hospital Brussels (UZ Brussel). Professor at the Vrije Universiteit Brussel and visiting professor at the University of Zagreb, with more than 20 years in reproductive medicine. His work focuses on ovarian stimulation, embryo transfer and assisted reproductive technologies, with more than 300 scientific publications.

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Body mass index has remained the default counselling tool in fertility clinics for decades — but it is increasingly clear that BMI conceals more clinical information than it reveals. The lecture argues for replacing it with body composition assessment as the new standard for pre-cycle workup, and for treating overweight, obesity and underweight as fundamentally different metabolic phenotypes.

BMI as an outdated criterion

Two patients with identical BMI can have fundamentally different fertility prospects. The same BMI can reflect normal composition in a constitutionally lean patient, high muscle mass in an athlete, or low fat-free mass in a malnourished patient. Using BMI as the sole criterion conflates these into a single category — losing the clinically relevant information.

Body composition as the new standard

A three-step workup operationalises this shift: bioelectrical impedance analysis (BIA) for fat and fat-free mass, indirect calorimetry for resting energy expenditure, and a structured food diary to identify under- or over-reporting. Together these tools allow targeted lifestyle recommendations rather than the generic «lose weight» message.

Couple-level fertility risk

Spontaneous fecundability shows a J-shaped relationship with BMI for both partners. Male obesity contributes through sperm DNA fragmentation and reduced concentration, motility and morphology — and the «obese woman with lean man» combination carries one of the worst fecundability ratios. Counselling that addresses only the female partner misses a substantial share of the risk.

Sustainable weight management, not starvation

Crash diets and meal-replacement programmes may show benefit for spontaneous conception but consistently fail to improve IVF outcomes — starvation worsens oxidative stress and oocyte quality. Sustainable weight management combined with body composition tracking is the only intervention that improves both spontaneous and ART outcomes simultaneously.

Obstetric versus embryologic thresholds

Cycle cancellation in morbid obesity (typically BMI >35) is driven by obstetric safety rather than embryologic outcomes. The two categories of risk follow different curves and require different counselling — and ART centres benefit from explicit, unit-specific thresholds with clear obstetric rationale.

Topics covered

  • BMI as an outdated criterion
  • Body composition assessment
  • Bioelectrical impedance and indirect calorimetry
  • Couple-level fertility (male obesity)
  • Sustainable weight loss vs starvation diets
  • Obstetric vs embryologic risk thresholds
  • Underweight subgroup and malnutrition
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Why do euploid embryos fail to implant.

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Christophe Blockeel

Christophe Blockeel

Reproductive endocrinologist and gynecologist, and Medical Director of Brussels IVF — the Centre for Reproductive Medicine at University Hospital Brussels (UZ Brussel). Professor at the Vrije Universiteit Brussel and visiting professor at the University of Zagreb, with more than 20 years in reproductive medicine. His work focuses on ovarian stimulation, embryo transfer and assisted reproductive technologies, with more than 300 scientific publications.

Author of the lecture "Overweight, obesity and reproductive outcomes"